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经皮给药系统又称经皮治疗系统,是指药物以一定的速率通过皮肤,经毛细血管吸收进 入体循环而产生药效的一类制剂。与传统的口服与皮下注射给药方式相比,经皮给药有许多 优点:可产生持久、恒定和可控的血药浓度;使因为体内新陈代谢迅速而半衰期很短的药物 活性明显提高;避免了肝脏的首过效应与胃肠道因素的干扰,将毒副作用降到最小;具有无 创或微创性,患者可自己用药,使用方便,可随时中断给药。这些独特的优势使其已成为第 三代药物制剂的研发重点。但是,受皮肤表面厚约 30~50 微米、非常致密的角质层的阻挡作 用,现在即使采用添加化学促渗剂等常规手段,使绝大多数药物(即便是剂量低、疗效高的 一些药物)的经皮渗透速度太低而无法达到所需的治疗剂量,因此产生的药效很低、很慢或 根本无效,这也是目前经皮给药贴剂的种类非常稀少的根本原因。同时,化学促渗剂的使用 往往还会引起皮肤过敏等其他毒副作用。
如何克服皮肤屏障作用,使药物在一定时间内的经 皮渗透量达到治疗量一直是许多透皮给药制剂开发与应用的关键。 为了大幅度提高药物/美容护肤品的经皮渗透性,近年来在国际上研发了多种方法,其中 尤以微针致孔法最受青睐,它首先是采用微针阵列(由多根按照一定间距排列的微针组成, 每根微针的长度、粗细为几十至几百微米)瞬间穿透皮肤最外面的角质层而产生许多微孔, 然后在皮肤表面涂覆药物/美容护肤品,也可以事先在微针上涂覆药物制备成微针给药/美容贴, 使用时再刺入皮肤。
微针致孔法能将药物/美容品的经皮渗透速率提高数万倍以上,给药剂量 最大,对药物的适用范围最广,理论上适合任何药物/美容护肤品而不受分子量大小、药物极 性、熔点等的限制,从而能够迅速使药物/美容护肤品穿透角质层进而扩散入体内发挥作用, 因此疗效显著;由于微针非常纤细、短小不会触及神经与血管,所以刺入皮肤时不会有痛感、 不会出血,操作简单、灵活、安全、方便,可随时中断给药,所以更容易被患者所接受。 微针阵列芯片制造技术成熟,其最大特点是全部采用现有医用材料并利 用成熟的加工工艺实现了高质量实心、空心不锈钢等金属微针阵列芯片的低成本批量制造。
凸出的微针高度根据需要可以灵活设置:300~800 微米,皮肤的柔韧性与钉床效应决定了只 有微针的针尖部分(约 20~200 微米)会真正刺入皮肤,由于该深度不会触及神经与血管而 无痛无血,安全可靠;微针密度与排布可以根据需要灵活多样;芯片衬底材料既可为刚性又 可为柔性,使用安全方便。
在实心/空心微针芯片上涂覆各种药物可以进一步制成相关药物 的经皮贴剂或给药系统,刺入皮肤后即可迅速持续释药。利用上述给药芯片/系统不仅可以 显著提高现有药物/美容护肤品的经皮渗透率,使药物或美容护肤品迅速通过角质层进入表 皮层及真皮层,明显提高药效或美容养颜效果,还可以扩展适用药物的种类,开发出更多药 物和化妆品的经皮新剂型。
2 效益分析
由于皮肤表面角质层的阻挡作用,目前绝大多数药物的经皮渗透速度太低而无法采用经 皮给药方式,即使在添加了化学促渗剂的情况下,全球上市的经皮药剂也只有约 30 种,虽 然无法评估通过经皮渗透进入体内的实际药物剂量,但其营业额仍高达 320 亿美元。
据国际 权威机构预测,在不久的将来,有三分之一左右的药品将会改为经皮输运,最终形成三大给 药剂型:口服、注射和经皮给药“三分天下”的市场态势。如果借助于微针阵列芯片,不仅 可以大幅度提高现有各种经皮贴剂的药效和减少甚至不再添加化学促渗剂,而且将使几乎所 有药物采用经皮给药方式成为可能;此外,以微针阵列芯片为载药的平台,可将药物预先固 定在微针针尖上制成类似“创可贴”式的给药贴剂,这样就可实现定量地直接将药物经皮无 痛植入人体皮内缓慢释放,载药量也更大,适用面更广,上述无疑会带来经皮输运药剂及其 应用的革命,因此创造出巨大的经济效益与社会效益。

为维护中技网平台交易秩序,保护技术需求方合法权益,本人(本单位)特做出以下承诺和声明:
一、本人(本单位)专利技术是经国家知识产权局审定认可,并取得了该项知识产权的专利证书,信息真实,技术可靠,无知识产权纠纷。
二、本人(本单位)愿意根据《中华人民共和国合同法》、《中华人民共和国专利法》、《中华人民共和国知识产权保护法》和《中华人民共和国促进科技成果转化法》以及中技网平台制定的技术转移交易规则和制度进行规范交易,自觉维护技术转移网络交易秩序。
三、如本人(本单位)在技术转移转化过程中有严重违规违约行为,给平台和交易相对方造成经济或财产损失,本人(本单位)愿意承担相应责任。

For maintenance or web platform trading order, protect the legal rights of the technical demand (units), make the following commitment and declaration:

1I (unit) patent technology is approved by the state intellectual property office and obtained the patent certificate of this intellectual property, the information is true, the technology is reliable, and there is no intellectual property dispute.

2, I (unit) willing to according to the law of the People's Republic of China contract law ", "patent law of the People's Republic of China, the intellectual property rights of the People's Republic of China protects a law" and "promote the conversion of scientific and technological achievements of the People's Republic of China" and wowed net platform to develop the trading rules and the system of technology transfer of regulate transactions, consciously safeguard the order of the technology transfer network transactions.

3.If I (unit) in the process of the transformation of technology transfer has seriously violated the breach, to economic or property damage caused by platform and trade each other, I (the unit) are willing to bear the corresponding legal responsibility.

交易规则说明

1、转让方在委托服务商转让期间,首先要认真阅读中技网会员协议和技术商品交易规则,其次要了解中技网有关收费标准,清楚应当遵守的相关权利和义务

2、购买方在中技网平台上认定购买某一项技术商品前,需要按照规定向中技网平台支付定金(完成意向性购买),但知识产权归属以及何时能够使用该项知识产权,视买卖双方协商确定后才能够使用,在此之前,建议您不要使用或侵犯他人的知识产权。

3、本网站对上传在首页各版块展示出售的技术产品实行有偿服务原则,对拟出售的专利技术产品交易价格以及市场前景,中技网将根据财政部无形资产评估有关标准和规定给予客观、公正的评价,具体收费标准请咨询客服人员。

1, the assignor in commissioned services during the transfer, the first thing to read or member agreement and the technical commodity trading rules, second to understand relevant charge standard or network platform, which shall comply with the relevant rights and obligations.

2, the purchaser on or network platform, decided to buy a certain technology products before, need to pay a deposit in accordance with the relevant provisions to or net platform (complete intentional purchase), but the intellectual property ownership and when to be able to use the intellectual property rights, after the negotiation between the buyers and sellers can use, before that, it is recommended that you do not use or infringe others' intellectual property.

3, this website to upload on the home page of each section shows the sale of products shall be paid for the service principle, to plans to sell the patent technology of the product market price and the market prospects, or network will according to the ministry of finance of intangible assets evaluation of relevant standards and regulations to give an objective and fair evaluation, specific charge standard, please consult customer service staff.

交易流程

根据中技网交易规则,技术买卖双方应当遵循友好、自愿和有偿原则进行交易,为此,请技术买卖双方应当遵循中技网制定的交易流程进行有序买卖。
一、买方确定购买意向→支付定金→签订意向性购买协议→买卖双方签订正式协议→买方付款 →办理技术转移交割手续→资金结算→交易完成→退还定金。

二、卖方提交信息资料→上传有效证明文件→平台审核→与平台签订相关协议和信用保证金协议→缴纳信用保证金→平台发布出让信息→确定买家→签订协议→出让技术→资金结算→交易完成→退还信用保证金。

    According to trading rules or network technology between buyer and seller shall follow the principle of friendly, voluntary and paid, for this, please technology between buyer and seller shall follow the wowed the orderly sale network of trading process.

One, the buyer to determine the purchase intentions to pay the deposit, intentional purchase agreement to sign a formal agreement between the seller and the buyer, the buyer's payment to delivery technology transfer formalities, fund settlement - deal - return deposit.

Second, the seller submit information to upload valid documents to review platform, and platform signed the relevant agreement and credit margin agreements to pay credit deposit, platform release transfer information to determine the buyer, signed an agreement to transfer technology, funds and settlements - deal - the refund credit deposit

重要提示

1、技术转让方请务必遵守《中华人民共和国合同法》、《中华人民共和国专利法》、《中华人民共和国知识产权法》、《中华人民共和国促进科技成果转化法》等相关法律法规,诚实守信,不得伪造或提供虚假技术信息。

2、技术购买方在决定购买技术商品前,首先要了解中技网的有关交易流程和技术转让方的详细信息,在购买过程中对有关技术信息产生疑问或不清楚的地方,请随时与技术信息发布单位取得联系。

3、中技网作为市场化运作的专业技术买卖服务平台,由中国技术市场协会主办,是国内权威的专业技术交易分类信息网,专业、专注、权威,面向国内外发布技术转让和技术需求项目信息,服务周到,信誉第一,交易规范,请客户认准中技网官方网址,切勿上当受骗。

1, technology transferor please be sure to abide by the law of the People's Republic of China contract law ", "patent law of the People's Republic of China" and "intellectual property law of the People's Republic of China", "promote the conversion of scientific and technological achievements of the People's Republic of China" and other relevant laws and regulations, the honest code of honor, are not allowed to fake or providing false information technology.

2 the purchaser prior to the decision to buy technology goods, technology, the first thing to understand the assignor or network related transaction process and technology of detailed information, in the process of buying to doubt the related technical information or unclear, please feel free to get in touch with technical information release unit.

3, or as a market-oriented operation of professional technology trading service platform, sponsored by the China technology market association, is the domestic authority of professional technology trading classified information network, professional, dedicated, authority, and the release technology transfer and technology at home and abroad demand project information, service, credit first, trade specification, please customers look or net official web site, please do not be deceived.

郑重声明

  会员在服务期内私自线下与相对交易方进行交易,由当事人自行承担法律后果,所产生的经济或知识产权纠纷中技网不承担任何法律责任。

Membership in the service period to offline, transacting business with relatively by the parties to bear the legal consequences, economic or intellectual property rights disputes or generated by the network does not assume any legal liability.

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