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在天然植物药的开发中,银杏叶的现代药用研究无疑是热点之一。七十年代初,德国首先用溶剂萃取的方法大规模生产具有明确质量标准的银杏叶提取物EGb761,为黄酮甙(含量在24%以上)和萜内酯(银杏内酯和白果内酯的总和,含量在6%以上)的混合物,并以此开发成了疗效显著、稳定的治疗心脑血管疾病的单方植物药,成为欧洲最为畅销的药品,引起了国际医药界极大的关注。
目前国内外上市的银杏制剂所用原料均符合EGb761的质量标准。但是,随着研究的深入,大量的药理和临床实验都证明了银杏叶提取物中的主要药效成分黄酮甙和萜内酯的药理作用并不完全相同,因此,单一有效成分新药成为近十年来欧美发达国家竞相开发的目标。
八十年代初,法国科学家P. Braquet领导的研究小组对银杏内酯的药理活性进行了研究,首次发现银杏内酯是一类非常有效的血小板活化因子(PAF)天然拮抗剂,血小板活化因子PAF是由血小板和多种炎症细胞产生和分泌的一种内源性磷脂,是迄今发现的最有效的血小板聚集诱导剂,具有广泛的生物学活性,它除导致血栓形成及参与心血管疾病的发生和发展以外,还与其它多种疾病的发生密切相关,如哮喘、休克、炎症、器官移植时的排斥反应等,因此PAF拮抗剂的研究一直是八十年代以来寻找上述疾病的特效和高效治疗药物的热点。另外,近年来的研究发现,除银杏内酯外,银杏萜内酯还包括另一类化合物,即白果内酯,它能有效抵抗神经末梢的衰老,对器质性神经系统疾病有明显的疗效,尤其对抑郁症的治疗极为有效,且无毒副作用。
银杏内酯口服,生物利用率很高,并能在1—2小时内迅速进入血液,这对一般疾病的治疗已不成问题,但用于急救,药效的发挥显得速度较慢,因此近年来国际上热衷于银杏内酯针剂的开发,这对于银杏内酯的制备提出了很高的要求。 为此,我们根据黄酮和萜内酯的结构特点,设计合成了一类兼具氢键、疏水、筛分多种作用的协同效应的吸附树脂,成功地将黄酮和内酯分离,可经吸附、洗脱一步制备含量高于90%的银杏内酯提取物。
技术原理与工艺流程简介
通过改变反应单体和交联剂,使得所需的功能基团在树脂聚合过程中即被引入到树脂骨架上,通过含有所需功能基的反应单体投料量的变化,控制树脂上功能基含量,使其与银杏黄酮类化合物可发生特异性吸附。由于避免苯环的引入,树脂的极性较大,对银杏内酯的吸附能力大大减弱,所以银杏内酯和黄酮得到有效分离。在此基础上,制备一类孔径均匀的具有筛分能力的吸附树脂,通过改变树脂初始交联度,使其在不同溶胀程度下发生后交联反应,可制备一系列孔径尺寸可调的树脂,通过吸附实验筛选,得到适宜孔径的树脂,用于银杏内酯粗提物中未知杂质的去除,使得银杏内酯含量达到90%。 详细考察吸附溶液浓度、吸附速度、洗脱液浓度、洗脱速度等操作条件对纯化效果的影响,建立最佳提取工艺。
应用领域、技术水平及能为产业解决的关键技术、
专利 应用领域为医药、材料行业,可提供低成本、高纯度的银杏内酯提取物(总内酯纯度高于90%),可进一步研究开发银杏内酯冻干粉针剂,用于脑梗塞(脑血栓形成、脑栓塞)中风中经络的痰瘀阻络症的临床治疗。
应用前景分析及效益预测
利用此种新型吸附树脂制备银杏内酯提取物,工艺简单,可直接用于工业化生产,且与溶剂萃取法相比,该法生产成本大大降低,因此在价格上这种提取物本身已极具市场竞争力,由此开发出的银杏内酯针剂,无疑应具有更强的竞争力和更广泛的应用前景。

为维护中技网平台交易秩序,保护技术需求方合法权益,本人(本单位)特做出以下承诺和声明:
一、本人(本单位)专利技术是经国家知识产权局审定认可,并取得了该项知识产权的专利证书,信息真实,技术可靠,无知识产权纠纷。
二、本人(本单位)愿意根据《中华人民共和国合同法》、《中华人民共和国专利法》、《中华人民共和国知识产权保护法》和《中华人民共和国促进科技成果转化法》以及中技网平台制定的技术转移交易规则和制度进行规范交易,自觉维护技术转移网络交易秩序。
三、如本人(本单位)在技术转移转化过程中有严重违规违约行为,给平台和交易相对方造成经济或财产损失,本人(本单位)愿意承担相应责任。

For maintenance or web platform trading order, protect the legal rights of the technical demand (units), make the following commitment and declaration:

1I (unit) patent technology is approved by the state intellectual property office and obtained the patent certificate of this intellectual property, the information is true, the technology is reliable, and there is no intellectual property dispute.

2, I (unit) willing to according to the law of the People's Republic of China contract law ", "patent law of the People's Republic of China, the intellectual property rights of the People's Republic of China protects a law" and "promote the conversion of scientific and technological achievements of the People's Republic of China" and wowed net platform to develop the trading rules and the system of technology transfer of regulate transactions, consciously safeguard the order of the technology transfer network transactions.

3.If I (unit) in the process of the transformation of technology transfer has seriously violated the breach, to economic or property damage caused by platform and trade each other, I (the unit) are willing to bear the corresponding legal responsibility.

交易规则说明

1、转让方在委托服务商转让期间,首先要认真阅读中技网会员协议和技术商品交易规则,其次要了解中技网有关收费标准,清楚应当遵守的相关权利和义务

2、购买方在中技网平台上认定购买某一项技术商品前,需要按照规定向中技网平台支付定金(完成意向性购买),但知识产权归属以及何时能够使用该项知识产权,视买卖双方协商确定后才能够使用,在此之前,建议您不要使用或侵犯他人的知识产权。

3、本网站对上传在首页各版块展示出售的技术产品实行有偿服务原则,对拟出售的专利技术产品交易价格以及市场前景,中技网将根据财政部无形资产评估有关标准和规定给予客观、公正的评价,具体收费标准请咨询客服人员。

1, the assignor in commissioned services during the transfer, the first thing to read or member agreement and the technical commodity trading rules, second to understand relevant charge standard or network platform, which shall comply with the relevant rights and obligations.

2, the purchaser on or network platform, decided to buy a certain technology products before, need to pay a deposit in accordance with the relevant provisions to or net platform (complete intentional purchase), but the intellectual property ownership and when to be able to use the intellectual property rights, after the negotiation between the buyers and sellers can use, before that, it is recommended that you do not use or infringe others' intellectual property.

3, this website to upload on the home page of each section shows the sale of products shall be paid for the service principle, to plans to sell the patent technology of the product market price and the market prospects, or network will according to the ministry of finance of intangible assets evaluation of relevant standards and regulations to give an objective and fair evaluation, specific charge standard, please consult customer service staff.

交易流程

根据中技网交易规则,技术买卖双方应当遵循友好、自愿和有偿原则进行交易,为此,请技术买卖双方应当遵循中技网制定的交易流程进行有序买卖。
一、买方确定购买意向→支付定金→签订意向性购买协议→买卖双方签订正式协议→买方付款 →办理技术转移交割手续→资金结算→交易完成→退还定金。

二、卖方提交信息资料→上传有效证明文件→平台审核→与平台签订相关协议和信用保证金协议→缴纳信用保证金→平台发布出让信息→确定买家→签订协议→出让技术→资金结算→交易完成→退还信用保证金。

    According to trading rules or network technology between buyer and seller shall follow the principle of friendly, voluntary and paid, for this, please technology between buyer and seller shall follow the wowed the orderly sale network of trading process.

One, the buyer to determine the purchase intentions to pay the deposit, intentional purchase agreement to sign a formal agreement between the seller and the buyer, the buyer's payment to delivery technology transfer formalities, fund settlement - deal - return deposit.

Second, the seller submit information to upload valid documents to review platform, and platform signed the relevant agreement and credit margin agreements to pay credit deposit, platform release transfer information to determine the buyer, signed an agreement to transfer technology, funds and settlements - deal - the refund credit deposit

重要提示

1、技术转让方请务必遵守《中华人民共和国合同法》、《中华人民共和国专利法》、《中华人民共和国知识产权法》、《中华人民共和国促进科技成果转化法》等相关法律法规,诚实守信,不得伪造或提供虚假技术信息。

2、技术购买方在决定购买技术商品前,首先要了解中技网的有关交易流程和技术转让方的详细信息,在购买过程中对有关技术信息产生疑问或不清楚的地方,请随时与技术信息发布单位取得联系。

3、中技网作为市场化运作的专业技术买卖服务平台,由中国技术市场协会主办,是国内权威的专业技术交易分类信息网,专业、专注、权威,面向国内外发布技术转让和技术需求项目信息,服务周到,信誉第一,交易规范,请客户认准中技网官方网址,切勿上当受骗。

1, technology transferor please be sure to abide by the law of the People's Republic of China contract law ", "patent law of the People's Republic of China" and "intellectual property law of the People's Republic of China", "promote the conversion of scientific and technological achievements of the People's Republic of China" and other relevant laws and regulations, the honest code of honor, are not allowed to fake or providing false information technology.

2 the purchaser prior to the decision to buy technology goods, technology, the first thing to understand the assignor or network related transaction process and technology of detailed information, in the process of buying to doubt the related technical information or unclear, please feel free to get in touch with technical information release unit.

3, or as a market-oriented operation of professional technology trading service platform, sponsored by the China technology market association, is the domestic authority of professional technology trading classified information network, professional, dedicated, authority, and the release technology transfer and technology at home and abroad demand project information, service, credit first, trade specification, please customers look or net official web site, please do not be deceived.

郑重声明

  会员在服务期内私自线下与相对交易方进行交易,由当事人自行承担法律后果,所产生的经济或知识产权纠纷中技网不承担任何法律责任。

Membership in the service period to offline, transacting business with relatively by the parties to bear the legal consequences, economic or intellectual property rights disputes or generated by the network does not assume any legal liability.

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